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Panax Notoginseng Saponins (PNS) are natural active ingredients extracted from the roots and stems of Panax notoginseng, a plant in the Araliaceae family. They mainly contain more than ten triterpene saponins, including ginsenosides Rg1, Rb1, Rd, and notoginsenoside R1. Its core pharmacological effects include: improving microcirculation by inhibiting platelet aggregation and regulating vascular endothelial function; clearing free radicals and enhancing SOD activity to resist oxidative stress; and inhibiting the NF-κB inflammatory pathway to reduce the release of pro-inflammatory factors such as TNF-α. Studies have shown that PNS can also induce apoptosis by blocking the tumor cell cycle (such as the S phase), and significantly inhibit angiogenesis of the chick chorioallantoic membrane in angiogenesis models.
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