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Asiaticoside is the core active ingredient of Centella asiatica (Centella asiatica) in the Apiaceae family, mainly containing asiaticoside, madecassoside and other pentacyclic triterpene esters. It has a wide range of pharmacological effects, exerting its efficacy by promoting fibroblast proliferation (collagen synthesis increased by 41.7%), inhibiting inflammatory pathways (such as NF-κB), and scavenging free radicals (DPPH scavenging rate up to 85%). Modern extraction techniques such as flash extraction can significantly enhance its anti-tumor activity, inducing apoptosis of tumor cells by activating the Bax/Caspase-3 pathway, with an inhibition rate exceeding 50% in a lung cancer model.
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Ginsenoside Rg1 is a core active ingredient of Panax ginseng, belonging to the protopanaxadiol-type triterpene saponins. Its chemical structure is based on a dammarane-type tetracyclic triterpene skeleton, modified by glycosylation to form unique pharmacological activity. Studies have shown that Rg1 has multi-target regulatory capabilities, including activating the Akt/GSK-3β pathway to protect neurons, promoting the release of vascular endothelial nitric oxide (NO) to improve microcirculation, and enhancing microglial phagocytosis through the AMPK signaling pathway. It has significant antioxidant activity, with a DPPH radical scavenging rate of 85%, and can improve superoxide dismutase (SOD) activity and reduce malondialdehyde (MDA) production.
