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Panax Notoginseng Saponins (PNS) are natural active ingredients extracted from the roots and stems of Panax notoginseng, a plant in the Araliaceae family. They mainly contain more than ten triterpene saponins, including ginsenosides Rg1, Rb1, Rd, and notoginsenoside R1. Its core pharmacological effects include: improving microcirculation by inhibiting platelet aggregation and regulating vascular endothelial function; clearing free radicals and enhancing SOD activity to resist oxidative stress; and inhibiting the NF-κB inflammatory pathway to reduce the release of pro-inflammatory factors such as TNF-α. Studies have shown that PNS can also induce apoptosis by blocking the tumor cell cycle (such as the S phase), and significantly inhibit angiogenesis of the chick chorioallantoic membrane in angiogenesis models.
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Panax Notoginseng Triol Saponins (PNTS) are triterpene saponins extracted from Panax notoginseng (Araliaceae). The core components are ginsenosides Rg1, R1, and Rb1. Their chemical structure is based on protopanaxadiol as the aglycone, exhibiting significant lipid solubility and biological activity. Pharmacological studies show that PNTS protects the cardiovascular system by inhibiting platelet aggregation (IC50=23.7μM), promoting the release of nitric oxide (NO) in vascular endothelial cells, scavenging free radicals (DPPH scavenging rate of 82.3%), and regulating the NF-κB inflammatory pathway.
As a food product with Panax notoginseng leaf extract as its core ingredient, the value of Panax notoginseng stem and leaf can be glimpsed from modern scientific research exploring the active ingredients of Panax notoginseng leaf.
