Specifications
| Packaging Specifications | 15kg/bag/barrel |
| Product Specifications | Rb3≥10%, Rb3≥15% (HPLC) |
| Implementation Standard | 2020 edition of the Chinese Pharmacopoeia, First Supplement |
| Production Registration Number | None |
Panax notoginseng leaf extract is a natural active ingredient extracted from the stems and leaves of Panax notoginseng (Araliaceae). The core components are total saponins of Panax notoginseng leaves (mainly 20 (S)-protopanaxadiol saponins such as ginsenosides Rb3, Rb1, and Rc), and it also contains flavonoids (such as quercetin-3-O-rutinoside) and polysaccharides. It has significant pharmacological activities, including sedation and calming (by inhibiting the central nervous system to prolong sleep time and improve symptoms of neurasthenia, with a total effective rate of 88.8%), anti-myocardial ischemia (reducing myocardial cell damage and improving electrocardiogram changes), lipid-lowering (reducing serum total cholesterol and triglyceride levels), antioxidant (scavenging free radicals and improving SOD activity), and anti-tumor (inhibiting the proliferation of various cancer cell lines such as gliomas and pancreatic cancer).
Application Areas
I. Pharmaceutical Field
1. Nervous system diseases: Preparations such as Qiye Shen'an dripping pills and Qiye Shen'an tablets significantly improve insomnia, anxiety, and migraine by regulating neurotransmitters, with a total clinical efficacy rate exceeding 95%.
2. Cardio-cerebrovascular protection: In myocardial ischemia-reperfusion injury models, it can reduce the infarct size and improve cardiac function, and is expected to be used in the future for adjuvant treatment of coronary heart disease.
3. Anti-tumor potential: Rare saponin 20 (S)-25-OCH3-PPD isolated from the leaves has a direct killing effect on lung cancer and breast cancer cells, providing a basis for the development of new anticancer drugs.
II. Cosmetics Field
1. Anti-aging repair: Gels containing Panax notoginseng leaf extract can improve skin elasticity and reduce wrinkles, and its antioxidant effect is superior to some vitamin C preparations. For example, the traditional formula "Panax notoginseng persimmon leaf paste" achieves whitening and freckle removal by inhibiting melanin production. Clinical tests show that long-term use can improve skin tone uniformity.
2. Sensitive skin care: It alleviates skin redness by regulating inflammatory factors (such as reducing IL-1β levels), enhances barrier function, and has no risk of hormone interference.
III. Functional Foods and Health Products
1. Metabolic regulation: Leaf extract can help regulate blood lipids, and functional beverages compounded with probiotics have entered the market verification stage, which can relieve fatigue and assist in fat reduction.
2. Immune enhancement: Polysaccharide components enhance immunity by activating macrophages and are suitable for development as sports nutrition supplements.
Development Prospects
1. Market growth: With the development of the entire Panax notoginseng industry chain, the comprehensive output value of Panax notoginseng in Wenshan Prefecture in 2023 reached 35.151 billion yuan. The utilization of leaf extract as a byproduct is in line with the trend of circular economy, and the market size is expected to grow by more than 8% annually in the next five years.
2. Technological innovation:
(1) Microbial transformation technology: Through the synergistic fermentation of Bacillus licheniformis and Hansenula polymorpha, the antioxidant capacity of leaf extract can be increased by more than 3 times, and relevant patents have been industrialized.
(2) Targeted delivery system: Nanoliposome encapsulation technology increases the transdermal absorption rate of Panax notoginseng leaf saponins by 2.5 times, showing stronger activity in anti-aging skin care products.
3. Cross-border expansion: From a single component to multi-target synergistic development, such as compounding with green tea extract to enhance anti-inflammatory effects, or combining with nano-carriers to develop tumor-targeted drugs.
4. Sustainability: High-value utilization of by-products such as leaves and stems can reduce raw material costs by more than 30% and reduce agricultural waste pollution.
Safety and Challenges
Acute toxicity tests show that the median lethal dose (LD50) of Panax notoginseng leaf extract is >5000 mg/kg, but individual allergic reactions (such as rashes) should be noted. The recommended concentration in cosmetics is 0.2%-1.0%, and the pH should be controlled to maintain stability. Current challenges include:
① The differences in saponin components between leaves and roots require further clarification of the pharmacodynamic mechanism;
② The action targets and clinical translation pathways of anti-tumor active ingredients still need further research;
③ It is necessary to strengthen the identification and publicity of Panax pseudoginseng (containing hepatotoxic pyrrolizidine alkaloids) to avoid misuse.
With the deepening of the natural ingredient trend and the increasing demand for precision medicine, the potential of Panax notoginseng leaf extract in neurodegenerative diseases, adjuvant cancer therapy, and high-end skin care products will be accelerated, becoming one of the core directions for the development of the whole Panax notoginseng plant.
Panax notoginseng leaf extract
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