Specifications

Packaging Specifications	20kg/bag/barrel
Product Specifications	Asiaticoside and madecassoside ≥55% (HPLC)
Implementation Standard	2020 edition of the Chinese Pharmacopoeia, First Supplement
Production Registration Number	ZTCB20230023滇

　　Total asiaticoside is the core active ingredient of Centella asiatica (L.) Urb., mainly including asiaticoside, madecassoside and other pentacyclic triterpene esters. It has a wide range of pharmacological effects, exerting its efficacy by promoting fibroblast proliferation (collagen synthesis increased by 41.7%), inhibiting inflammatory pathways (such as NF-κB), and scavenging free radicals (DPPH scavenging rate up to 85%). Modern extraction technologies such as flash extraction can significantly enhance its anti-tumor activity, inducing tumor cell apoptosis by activating the Bax/Caspase-3 pathway, with an inhibition rate exceeding 50% in lung cancer models.

　　Application Areas

　　I. Pharmaceuticals and Health

　　1. Wound Repair: Clinical evidence confirms that asiaticoside cream (containing 2.75% total asiaticoside) can accelerate the healing of surgical incisions and burns, reducing scar hyperplasia. In the treatment of scleroderma, it improves skin elasticity recovery rate by 32% by inhibiting the TGF-β/Smad signaling pathway.

　　2. Cardiovascular Protection: Health products containing total asiaticoside can improve coronary blood flow (increase by 28%) in myocardial infarction models, reduce infarct size (from 36.5% to 13.6%), and lower serum creatine kinase (CK) activity.

　　3. Neurodegenerative Diseases: In Alzheimer's disease models, asiaticoside reduces neuroinflammation by inhibiting the p38 MAPK pathway, improving cognitive function (Morris water maze escape latency shortened by 22%).

　　II. Cosmetic Applications

　　Total asiaticoside is mainly used in skin care products in the form of high-purity extracts (70%-98%), with the following unique advantages:

　　1. Deep Repair and Anti-aging: Activates collagen synthesis genes in dermal fibroblasts, promoting the production of type I and III collagen. A face cream containing 2.5% total asiaticoside can significantly increase the wound healing area, and granulation tissue formation is more complete. Clinical tests show that its repair effectiveness for chloasma and acne marks reaches 85%.

　　2. Sensitive Skin Adaptability: By inhibiting the release of inflammatory mediators and enhancing skin immunity, it alleviates sensitive symptoms such as redness and dryness. Experiments have confirmed that 0.1-0.35% concentration of total asiaticoside can significantly improve skin elasticity and luster, and there is no risk of hormone interference, suitable for post-medical beauty repair.

　　3. Metabolic Activation and Permeability: Its small molecular structure allows it to quickly penetrate the epidermis and reach the dermis to exert its effects. It can promote the metabolism of keratinocytes, accelerate the shedding of aged keratin, and stimulate the proliferation of epidermal stem cells, making the skin smooth.

　　4. Brand Application Examples: International brands such as Kiehl's and SkinCeuticals use it in high-end repair serums, while domestic brands such as Fuyuan Asiaticoside Cream use it at a concentration of 0.2% directly for acne mark and scar care.

　　III. Functional Foods

　　1. Metabolic Regulation: Functional beverages containing total asiaticoside can lower total serum cholesterol (reduction of 19.2%) in hyperlipidemic rats and increase high-density lipoprotein (12.8%). Sports supplements combined with creatine can prolong exhaustive swimming time by 37.6%, relieving fatigue by inhibiting lactic acid accumulation.

　　2. Immune Enhancement: The total asiaticoside component in ginseng exosomes can activate T cell function, inhibit cell proliferation and promote apoptosis in liver cancer models, providing a new direction for immune-regulating health foods.

　　Development Prospects

　　1. Market Growth: In 2024, the market size of total asiaticoside in China exceeded 2 billion yuan, and is expected to reach 2.3 billion yuan in 2025, with a compound annual growth rate of over 15%. The global market is expanding at an annual growth rate of 8.2%, and will reach US$520 million in 2030, with the pharmaceutical and cosmetic sectors accounting for over 60%.

　　2. Technological Innovation

　　(1) Precise Extraction: Supercritical CO2 extraction combined with molecularly imprinted nano-magnetic bead technology can increase the purity of total asiaticoside to 98% and achieve efficient separation from other components.

　　(2) Targeted Delivery: Total asiaticoside encapsulated in neutrophil membrane vesicles has a 3-fold increase in targeted enrichment rate in stroke models, significantly enhancing neurorepair effects.

　　3. Cross-border Expansion: From a single component to multi-target synergistic development, such as combining with probiotics to regulate gut microbiota, or combining with nanocarriers to develop targeted drugs for Alzheimer's disease. In the cosmetics field, it is combined with glabridin and plant retinol A to form a synergistic system of anti-aging, antioxidant, and repair.

　　4. Sustainability: Utilizing by-products such as ginseng stems and leaves and insect molts to extract total asiaticoside reduces raw material costs by over 30% and meets EU cosmetic safety standards. Fermentation technology simultaneously degrades heavy metals and pesticide residues, promoting green production.

　　Challenges and Responses

　　Mechanism Deepening: The molecular pathways of anti-tumor and neuroprotection have not been fully elucidated, and further research needs to be combined with single-cell sequencing and organoid models.

　　Quality Standards: The 2025 edition of the Chinese Pharmacopoeia plans to increase the purity standard of total asiaticoside from 40% to 50%, promoting industry technological upgrades.

　　Safety Optimization: Although the acute toxicity LD50 > 6400mg/kg, high-dose coagulation dysfunction (incidence of about 0.3%) should be guarded against, and clinical monitoring should be strengthened.

　　With the deepening trend of natural ingredients and the growing demand for precision medicine, the potential of asiaticoside in wound repair, cardiocerebrovascular protection, and high-end personal care will be accelerated, becoming a benchmark ingredient in the development of plant extracts.

Asiaticoside is the core active ingredient of Centella asiatica (Centella asiatica) in the Apiaceae family, mainly containing asiaticoside, madecassoside and other pentacyclic triterpene esters. It has a wide range of pharmacological effects, exerting its efficacy by promoting fibroblast proliferation (collagen synthesis increased by 41.7%), inhibiting inflammatory pathways (such as NF-κB), and scavenging free radicals (DPPH scavenging rate up to 85%). Modern extraction techniques such as flash extraction can significantly enhance its anti-tumor activity, inducing apoptosis of tumor cells by activating the Bax/Caspase-3 pathway, with an inhibition rate exceeding 50% in a lung cancer model.